Fig. 1: TAK-653 enhanced TMS-evoked motor responses in rats.
From: Transcranial magnetic stimulation as a translational biomarker for AMPA receptor modulation
A Example of an animal placement on the stereotaxic apparatus, a small figure-eight coil, and an accelerometer attached to the hind paws. B Representative waveforms in three dimensions (pictured in different colors) used for MMG calculation with vehicle or five different doses of TAK-653. C Summary graph illustrating the MMG vectoral amplitude over time for all six treatment groups (mean ± SEM). All TAK-653 doses except for 0.1 mg/kg increased MMG amplitude. No dose–response effect was observed. D Plasma and brain TAK-653 levels 2 h after administration via oral gavage in rats with the four effective doses. MMG, mechanomyography; spTMS, single-pulse transcranial magnetic stimulation; TMS, transcranial magnetic stimulation.
