Fig. 1: Polygenic overlap between neuroticism (NEUR) conditioned on CAD (NEUR∣CAD) and CAD conditioned on NEUR (CAD∣NEUR). | Translational Psychiatry

Fig. 1: Polygenic overlap between neuroticism (NEUR) conditioned on CAD (NEUR∣CAD) and CAD conditioned on NEUR (CAD∣NEUR).

From: Shared genetic architecture between neuroticism, coronary artery disease and cardiovascular risk factors

Fig. 1

Conditional q–q plots of nominal versus empirical –log 10p values (corrected for inflation) in primary trait (NEUR or CAD) below the standard GWAS threshold of P < 5 × 10–8 as a function of significance of association with secondary trait (CAD or NEUR) at the level of P < 0.1, P < 0.01, and P < 0.001, respectively. The blue line indicates all SNPs. The dashed line indicate the null hypothesis.

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