Table 1 Loci shared between neuroticism and more than one secondary phenotype.

From: Shared genetic architecture between neuroticism, coronary artery disease and cardiovascular risk factors

Phenotype

CHR

LEAD SNP

MinBP

MaxBP

BMI, TG, WHR, SBP AND PP

1

rs1460940

72628347

72959392

SBP, DBP, BMI AND PP

2

rs736699

26911509

26932796

SBP AND PP

2

rs343968

44905806

45004016

SBP, BMI AND PP

2

rs848286

58007905

58674393

CAD, BMI AND PP

2

rs72932707

203639395

204196618

HDL AND DBP

2

rs6738482

61242410

61837947

WHR AND DBP

2

rs17741344

148457576

148853296

TC AND LDL

3

rs9853387

135798730

136503896

CAD, BMI, HDL, LDL, TC AND PP

3

rs6788993

52277445

52838402

SBP, BMI AND PP

3

rs12637791

85403892

85784084

TC, DBP AND SBP

3

rs1989839

50184538

50420554

CAD, DBP AND SBP

4

rs4691707

156420605

156443314

SBP AND PP

4

rs16854051

41879969

42161491

BMI, DBP AND SBP

4

rs11722027

144028173

144215346

CAD, T2D AND DBP

4

rs17516389

118976252

119264162

BMI AND PP

5

rs4269288

122650049

122803786

T2D, DBP, SBP AND PP

6

rs10948071

43260660

43397259

WHR, TG, LDL, CRP AND PP

6

rs2856674

25450026

32963948

HDL, CRP, LDL, TC, TG AND SBP

6

rs2269426

31578772

32189481

CAD, WHR, CRP AND SBP

6

rs1490384

126659043

127080700

CAD, HDL, LDL, WHR, BMI, CRP AND DBP

6

rs1077393

30997692

32189481

T2D AND DBP

6

rs2396004

43262303

43364494

CAD, WHR, CRP, T2D AND DBP

6

rs6925689

126623947

127080700

TC AND LDL

7

rs6948810

21474610

21555536

SBP AND PP

7

rs17165701

12212919

12286050

CAD AND SBP

7

rs58673065

1843200

2110850

CAD AND SBP

7

rs6460902

12200060

12285140

DBP, HDL, BMI, LDL AND PP

8

rs7813434

116464988

116632819

CRP, DBP, SBP AND PP

8

rs2736313

8088230

12199830

WHR AND PP

9

rs11791636

23805555

23827667

SBP AND PP

9

rs10821154

96155812

96381916

SBP AND PP

9

rs4838254

127766897

128399285

SBP, CAD, BMI AND PP

10

rs11000925

75867193

76421529

T2D, DBP AND SBP

10

rs10906382

13479684

13611368

CAD, BMI, DBP, SBP AND PP

10

rs77335224

104487871

105059896

BMI, LDL AND TC

11

rs866901

77909014

78135704

HDL OG TG

11

rs10832027

13354509

13370535

SBP, BMI AND PP

11

rs3180446

45203212

45345244

SBP, CAD, BMI, LDL,TC AND PP

11

rs2450122

77909014

78135704

HDL AND SBP

11

rs1988724

9958403

10370675

BMI AND SBP

11

rs11038371

45258966

45345244

BMI, T2D, CRP, TC, TG, HDL, LDL, PP, DBP, AND SBP

11

rs7107356

47175327

49128599

CAD, BMI, LDL, TC AND SBP

11

rs990706

77909014

78271614

SBP AND PP

12

rs79601649

49737114

50160662

HDL OG TC

14

rs12588415

75120628

75378185

TC, SBP AND PP

14

rs1866628

75057809

75113506

HDL,TC AND DBP

14

rs8004084

75144618

75377692

BMI AND PP

15

rs4886937

78076272

78152626

CAD, SBP, DBP AND PP

15

rs17514846

91412850

91429042

BMI AND SBP

15

rs7176782

69415482

69569464

CAD AND SBP

15

rs17514846

91412850

91429042

TC AND LDL

16

rs1002252

71278016

71376751

BMI, TG AND DBP

16

rs1549299

30916129

31155458

TC AND LDL

17

rs12309

38122708

38219005

TC AND LDL

17

rs1230065

43461460

43534322

SBP AND PP

17

rs2165846

44941366

44947821

CAD AND DBP

17

rs55938136

43798360

43798360

CAD, BMI, WHR, HDL

18

rs17700144

57728947

57987859

HDL OG TG

19

rs10409835

32830261

32994338

BMI AND WHR

19

rs9636202

18449238

18474892

Z in NEUR

Nearest gene

4.35461662317

RPL31P12

4.18963785615

KCNK3

−3.89234482431

CAMKMT

5.45230886725

FANCL

4.13516480072

ICA1L

4.45360597614

USP34

5.54325499552

ACVR2A

−4.98578731358

PCCB

4.29741691262

SMIM4:PBRM1

−5.00576709809

CADM2

−5.10311943356

ZMYND10-AS1:ZMYND10

−4.35330561706

MTND1P22

−5.43567296604

BEND4

3.94478982621

RP11–284M14.1

−4.33016153627

PRSS12

−4.89325849576

CEP120

−4.08127148845

ZNF318

5.47679437498

MTCO3P1

7.85464688518

TNXB:ATF6B

−5.2537909447

MIR588

−5.66008277462

BAG6

3.72892286408

ZNF318

4.68322226982

RNU6–200P

5.17023483889

SP4

−6.05105534044

TMEM106B

4.4437848434

MAD1L1

5.92306285077

TMEM106B

4.17514218028

TRPS1

−5.84975419193

LINC00529

−4.68062619372

ELAVL2

5.23143409848

FAM120A

−4.98786564489

HSPA5

−4.11173316994

ADK

−4.36400954759

BEND7

−5.23859919803

C10orf32-ASMT:AS3MT

−4.31225213337

GAB2

−5.43398246143

ARNTL

−4.74001727338

SYT13

4.27353276097

GAB2

4.6699316277

SBF2

4.02407371564

SYT13

−7.04747006968

AGBL2

−4.17713795565

RP11–452H21.4

4.76020126525

SPATS2

6.86308309352

YLPM1

4.64137402432

LTBP2

−6.54353852104

YLPM1

5.66999702405

LINGO1

−4.43830518151

FURIN

−3.94284707938

GLCE

−4.43830518151

FURIN

−5.2061488614

HYDIN

4.47612498022

PRSS36

−4.91571280463

MED24

−6.04762128386

ARHGAP27

4.77322394436

WNT9B

−11.5419461181

CRHR1:RP11–105N13.4

−5.50787070534

RPS3AP49

−5.29319139928

AC007773.2

−3.89258923647

PGPEP1

  1. BP base position, CHR chromosome, NEUR neuroticism, CAD coronary artery disease, BMI body mass index, WHR waist-hip-ration, HDL high density lipoprotein (HDL), LDL low density lipoprotein, TG triglycerides, TC total cholesterol, T2D, CRP c-reactive protein, SBP systolic blood pressure, DBP diastolic blood pressure, PP pulse-pressure, CIGPRDAY cigarettes smoked per day.
Back to article page