Fig. 2: The NLRP3 inflammasome might be involved in antidepressive effect of catalpol. | Translational Psychiatry

Fig. 2: The NLRP3 inflammasome might be involved in antidepressive effect of catalpol.

From: Catalpol ameliorates depressive-like behaviors in CUMS mice via oxidative stress-mediated NLRP3 inflammasome and neuroinflammation

Fig. 2

a–c Detection of NLRP3 inflammasome in the hippocampus of CUMS mice. Western blot analysis of (a) NLRP3 (n = 6–8/group), (b) cleaved caspase-1 (n = 6–8/group), and (c) Il-1β (n = 6–8/group). All data are expressed as the mean ± SD. *p < 0.05, compared with control group; ##p < 0.01, compared with vehicle group. d–h In order to detect whether or not NLRP3 inflammasome plays a key role in CUMS-induced depression, NLRP3 KO mice were used in this experiment. d The experimental paradigm and the experimental group. e The time spent immobile in the FST (n = 10/group). f Rearing numbers in the OFT (n = 10/group). g Total distance traveled in the OFT (n = 10/group). h Open-arm time proportion in the EPM test (n = 10/group). All data are expressed as the mean ± SD. **p < 0.01, ***p < 0.001, compared with wild-type group.

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