Fig. 5: Mitochondrial oxidative stress might be involved in the downregulation of proinflammatory cytokines by catalpol. | Translational Psychiatry

Fig. 5: Mitochondrial oxidative stress might be involved in the downregulation of proinflammatory cytokines by catalpol.

From: Catalpol ameliorates depressive-like behaviors in CUMS mice via oxidative stress-mediated NLRP3 inflammasome and neuroinflammation

Fig. 5

The expression of cytokines in hippocampus were assessed by qRT-PCR, the level of (a) IL-1β (n = 5–8/group), (b) IL-6 (n = 5–8/group), and (c) iNOS (n = 5–8/group) was downregulated significantly by catalpol. d, e There are no significant differences in the expression of (d) IL-10 (n = 5–8/group) and (e) CD206 (n = 5–8/group) between groups. All data are expressed as the mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001, compared with control group; #p < 0.05, ###p < 0.001, compared with vehicle group.

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