Table 1 Characteristics of study completers only, at each wave.
n | Wave 2 | n | Wave 3 | n | Wave 4 | n | Wave 5 | |
|---|---|---|---|---|---|---|---|---|
Sociodemographic | ||||||||
Age, years | 300 | 72.5 (0.7) | 297 | 76.2 (0.7) | 296 | 79.3 (0.6) | 300 | 82.0 (0.5) |
Female, n (%) | 300 | 147 (49.0%) | 300 | 145 (48.8%) | 296 | 143 (48.3%) | 300 | 147 (49.0%) |
Education, years | 300 | 11.0 (1.2) | 297 | 11.0 (1.2) | 296 | 11.0 (1.2) | 300 | 11.0 (1.2) |
Vascular risk | ||||||||
Hypertension history, n (%) | 300 | 135 (45.0%) | 297 | 157 (52.9%) | 296 | 172 (58.1%) | 300 | 176 (58.7%) |
Systolic blood pressure, mmHg | 297 | 145.6 (18.0) | 293 | 146.4 (17.5) | 291 | 144.2 (17.9) | 294 | 147.2 (20.2) |
Diastolic blood pressure, mmHg | 297 | 79.4 (9.2) | 293 | 80.0 (9.4) | 291 | 78.4 (9.5) | 294 | 78.6 (10.5) |
Diabetes history, n (%) | 300 | 20 (6.7%) | 297 | 26 (8.8%) | 296 | 31 (10.5%) | 300 | 33 (11.0%) |
HbA1c, mmol/mol | 290 | 38.8 (5.8) | 283 | 40.7 (7.1) | 281 | 40.5 (7.9) | 280 | 40.2 (8.0) |
Cholesterol, mmol/l | 291 | 5.3 (1.1) | 275 | 5.1 (1.2) | 287 | 5.1 (1.1) | 284 | 4.9 (1.2) |
Cardiovascular disease history, n (%) | 300 | 83 (27.7%) | 297 | 103 (34.7) | 296 | 110 (37.2%) | 298 | 118 (39.6) |
Smoking status, n (%) | 300 | Ever = 141 (47.0%); Never = 159 (55.0%) | 297 | Ever = 134 (45.1%); Never = 163 (54.9%) | 296 | Ever = 137 (46.3%); Never = 159 (53.7%) | 300 | Ever = 133 (44.3%); Never = 167 (55.7%) |
Cognitive | ||||||||
Moray House Test age-11 (max. 76) | 283 | 51.2 (11.5) | 280 | 51.2 (11.5) | 279 | 51.3 (11.5) | 283 | 51.2 (11.5) |
Neuroimaging | ||||||||
Total WMH volume cm3 | 298 | 10.5 (11.3) | 258 | 14.8 (14.6) | 252 | 19.2 (16.9) | 241 | 22.4 (18.8) |
Total brain volume cm3 | 300 | 991.9 (87.2) | 258 | 976.0 (86.8) | 252 | 964.4 (88.0) | 241 | 947.3 (85.5) |
PVS count | 300 | 251.8 (92.5) | ||||||
Lacunes, n (%) | 300 | Present = 13 (4.3%); Absent = 287 (95.7%) | ||||||
Microbleeds, n (%) | 300 | Present = 33 (11.0%); Absent = 267 (89.0%) | ||||||
