Table 2 Characteristics of the study sample at each wave.
n | Wave 2 (n = 540) | n | Wave 3 (n = 463) | n | Wave 4 (n = 372) | n | Wave 5 (n = 300) | |
|---|---|---|---|---|---|---|---|---|
Sociodemographic | ||||||||
Age, years | 540 | 72.5 (0.5) | 463 | 76.2 (0.7) | 372 | 79.5 (0.6) | 300 | 82.0 (0.5) |
Female, n (%) | 540 | 252 (46.7%) | 463 | 217 (46.9%) | 372 | 195 (52.4%) | 300 | 147 (49.0%) |
Education, years | 540 | 10.9 (1.2) | 463 | 10.9 (1.2) | 372 | 10.9 (1.2) | 300 | 11.0 (1.2) |
Vascular risk | ||||||||
Hypertension history, n (%) | 540 | 259 (48.0%) | 462 | 251 (54.3%) | 372 | 218 (58.6%) | 300 | 176 (58.7%) |
Systolic blood pressure, mmHg | 534 | 146.5 (18.0) | 458 | 147.4 (18.5) | 366 | 144.2 (17.9) | 294 | 147.2 (20.2) |
Diastolic blood pressure, mmHg | 534 | 79.7 (18.0) | 458 | 80.3 (9.8) | 366 | 78.2 (9.7) | 294 | 78.6 (10.5) |
Diabetes history, n (%) | 540 | 54 (10.0%) | 463 | 52 (11.2%) | 371 | 42 (11.3%) | 300 | 33 (11.0%) |
HbA1c mmol/mol | 518 | 39.0 (6.4) | 438 | 40.8 (7.1) | 348 | 40.4 (8.0) | 280 | 40.2 (8.0) |
Cholesterol, mmol/l | 521 | 5.2 (1.1) | 426 | 5.0 (1.2) | 360 | 5.0 (1.2) | 284 | 4.9 (1.2) |
Cardiovascular disease history, n (%) | 540 | 154 (28.5%) | 463 | 152 (32.8%) | 372 | 135 (36.3%) | 298 | 118 (39.6) |
Smoking status, n (%) | 540 | Ever = 274 (50.7%); Never = 266 (49.3%) | 462 | Ever = 218 (47.2%); Never = 244 (52.8%) | 372 | Ever = 204 (54.8%); Never = 168 (45.2%) | 300 | Ever = 167 (55.7%); Never = 133 (44.3%) |
Cognitive | ||||||||
Moray House Test age-11 (raw score, max 76) | 511 | 50.2 (11.9) | 437 | 50.9 (11.6) | 372 | 51.1 (11.7) | 283 | 51.2 (11.5) |
Neuroimaging | ||||||||
WMH volume cm3 | 537 | 12.2 (12.8) | 387 | 16.4 (15.3) | 309 | 20.5 (17.7) | 241 | 22.4 (18.8) |
Total brain volume cm3 | 533 | 993.7 (88.4) | 387 | 976.4 (88.5) | 309 | 965.4 (87.0) | 241 | 947.3 (85.5) |
PVS count | 540 | 258.7 (94.6) | ||||||
Lacunes, n (%) | 540 | Present = 28 (5.1%); Absent = 512 (94.9%) | ||||||
Microbleeds, n (%) | 540 | Present = 65 (12.0%); Absent = 475 (88.0%) | ||||||
