Table 3 Factor-of-curves models of associations between total SVD burden and the slope of latent cognitive variables between the ages of 73 and 82a.

From: Cerebral small vessel disease burden and longitudinal cognitive decline from age 73 to 82: the Lothian Birth Cohort 1936

 

Slope

Standardised β (SE)

95% CI

Uncorrected p-value

FDR-corrected p-valueb

General cognitive ability

−0.191 (0.08)

−0.351, −0.031

0.019

0.026

 + age + sex

−0.200 (0.08)

−0.358, −0.042

0.013

0.022

 + age + sex + vascular risk

−0.198 (0.08)

−0.355, −0.041

0.013

0.022

 + age + sex + vascular risk + childhood cognitive ability

−0.201 (0.08)

−0.363, −0.039

0.015

0.022

Processing speed

−0.189 (0.09)

−0.364, −0.013

0.035

0.047

 + age + sex

−0.223 (0.09)

−0.399, −0.046

0.013

0.022

 + age + sex + vascular risk

−0.222 (0.09)

−0.397, −0.047

0.013

0.022

 + age + sex + vascular risk + childhood cognitive ability

−0.222 (0.09)

−0.401, −0.044

0.015

0.022

Verbal memory

−0.139 (0.10)

−0.340, 0.061

0.174

0.223

 + age + sex

−0.092 (0.11)

−0.302, 0.117

0.388

0.428

 + age + sex + vascular risk

−0.094 (0.11)

−0.304, 0.115

0.377

0.428

 + age + sex + vascular risk + childhood cognitive ability

−0.102 (0.11)

−0.315, 0.110

0.345

0.410

Visuospatial ability

−0.179 (0.22)

−0.602, 0.245

0.408

0.435

 + age + sex

−0.157 (0.22)

−0.579, 0.265

0.466

0.466

 + age + sex + vascular risk

−0.162 (0.22)

−0.589, 0.265

0.457

0.466

 + age + sex + vascular risk + childhood cognitive ability

−0.171 (0.18)

−0.527, 0.185

0.346

0.410

  1. Four separate models were run for each cognitive factor, adding covariates in a stepwise manner. Likelihood ratio test statistic (LR) and degrees of freedom (DF) for each of the unadjusted models were as follows: General cognitive ability (LR = 6.79; DF = 30), processing speed (LR = 0.22; DF = 2), verbal memory (LR = 2.95; DF = 1), visuospatial ability (LR = 1.54; DF = 2). SVD burden-cognitive intercept associations from these models are presented in Table S3.
  2. CI confidence interval, FDR false discovery rate, SE standard error.
  3. aNote that the cognitive domains will contain any variance due to general cognitive ability.
  4. bFDR correction was conducted across results presented in this table and in Table S3.
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