Table 4 Univariate and multivariate associations of total life adversity, adversity during sensitive periods, and mental health with the endotoxin tolerance phenotype.

From: Adversity in early life and pregnancy are immunologically distinct from total life adversity: macrophage-associated phenotypes in women exposed to interpersonal violence

 

Endotoxin tolerance immunosuppressive phenotype

 

β

t-test

p-value

Univariate associations (Mental health)

 PTSD symptom severity (PSSI), df = 40

0.115

0.730

0.470

 Depressive symptoms (CESD-R), df = 40

0.189

1.216

0.231

Multivariate model 1 (df = 36)

 Total life adversity

−0.442

−2.607

0.031*

 Early life adversity

0.118

0.741

0.464

 Adversity in pregnancy

0.213

1.375

0.178

Multivariate model 2 (df = 36)

 Total life adversity

−0.374

−2.321

0.026*

 PTSD symptom severity (PSSI)

0.034

0.143

0.887

 Depressive symptoms (CESD-R)

1.182

0.805

0.426

  1. Univariate associations show that neither mental health factor is significantly associated with the phenotype in regression analyses (equivalent here to Pearson correlations). Multivariate models 1 and 2 demonstrate the relative independent association of total life adversity from adversity during sensitive periods and from mental health symptoms.
  2. PSSI PTSD symptom scale interview, total score, CESD-R Center for Epidemiologic Studies depression scale, total score.
  3. *p ≤ 0.05, †p ≤ 0.10.
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