Fig. 3: There is no evidence for clusters of highly correlating genes that are altered in MDD compared to HC. | Translational Psychiatry

Fig. 3: There is no evidence for clusters of highly correlating genes that are altered in MDD compared to HC.

From: No evidence for differential gene expression in major depressive disorder PBMCs, but robust evidence of elevated biological ageing

Fig. 3

A Gene co-expression heatmap highlighting the presence of clusters of highly correlating genes in PBMC data. The x and y-axis show the 5356 highly correlating genes. The colour intensity indicates the spearman correlation value between two given genes with blue as low and yellow as high. To highlight the presence of co-expression clusters the heatmap has been hierarchically clustered on both axes using Spearman distances, with UPMGA agglomeration and mean reordering. B Gene expression heatmaps for six gene co-expression clusters, highlighting the consistency between the expression pattern of all genes within a cluster across all 231 samples. Samples are given by column and cluster genes by row. Colour intensity indicated row scaled (z-score) gene expression, with blue as low and yellow as high. C Gene expression boxplots for the six clusters with the lowest p-value (T-test) for HC vs MDD. Showing sample group on the x-axis and the cluster metagene expression (mean z-score) on the y-axis. All clusters are non-significant with adjusted p > 0.25.

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