Table 2 Shared loci between bipolar disorder and cardiovascular disease phenotypes.

From: Extensive bidirectional genetic overlap between bipolar disorder and cardiovascular disease phenotypes

Associated phenotype

Shared loci (n) conjFDR

Concordant effect (%)

Genetic correlation

CVD phenotypes

   

BMIa

69

52.2%

−0.06 (p = 0.010)

SBP

53

49.1%

0.02 (p = 0.396)

DBP

53

47.2%

0.04 (p = 0.155)

TC

15

26.7%

0.02 (p = 0.463)

LDL

13

46.2%

0.03 (p = 0.346)

HDL

10

40.0%

−0.02 (p = 0.471)

T2D

4

25.0%

−0.04 (p = 0.422)

CAD

10

70.0%

−0.02 (p = 0.539)

  1. Number of shared loci at conjFDR<0.05, concordant effect directions in percentage, and genetic correlation estimated by LD score regression.
  2. BIP bipolar disorder, CVD cardiovascular disease, SBP systolic blood pressure, DBP diastolic blood pressure, BMI body mass index, TC total cholesterol, HDL high-density lipoprotein cholesterol, LDL low-density lipoprotein cholesterol, T2D type 2 diabetes mellitus, CAD coronary heart disease, conjFDR conjunctional FDR.
  3. aThe results for BMI & BIP are retrieved from Bahrami et al. [24].
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