Fig. 1: Correlation expression matrix of the GWAS-derived genes.
From: Genome wide analysis implicates upregulation of proteasome pathway in major depressive disorder
The color in each entry (x,y) represents the correlation between the expression of genes x and y, along with all MDD samples in the specified brain region. Red color indicates high-correlated expression and blue, low. We used the SPIN tool [40]) to sort the list of genes so that genes with similar expression patterns would be grouped together. A The Pearson correlation expression matrix of the 23 GWAS-derived genes was calculated along with hippocampal (HPC) samples of MDD patients (GSE53987 data). Note that 23 of the 37 GWAS-derived genes were present in GSE53987. The orange rectangle represents the cluster of genes with highly correlated expression. B The Pearson correlation expression matrix of 23 randomly selected genes was calculated along with HPC samples of persons with MDD (GSE53987 data). C The Pearson correlation expression matrix of the 28 GWAS-derived genes calculated along parietal cortex (PC) samples of MDD patients (GSE53978 data). Note that 28 of the 37 GWAS-derived genes were present in GSE53978. The orange rectangle represents the cluster of genes with highly correlated expression. D The Pearson correlation expression matrix of 28 randomly selected genes was calculated along with PC samples of persons with MDD (GSE53978 data).
