Fig. 3: Pathway-based differential expression analysis of the ubiquitin-proteasome dependent proteolysis superpathway.
From: Genome wide analysis implicates upregulation of proteasome pathway in major depressive disorder
A Differential expression of the ubiquitin-proteasome-dependent proteolysis superpathway measured on dorsolateral prefrontal cortex (DLPFC) (GSE92538) data. The colors of the nodes represent the deviation in expression of the MDD samples from the healthy control group; the edges represent relations of co-expression of the STRING database (see Supplementary Methods section 7). Only genes with relation to at least one other gene in the superpathway are displayed. The yellow circle represents a subgroup of highly interconnected proteasome subunit genes. B The same as in A) for the hippocampal (HPC) (GSE53987) data. C The same as in A) for the striatal (STR) (GSE53987) data. D The same as in (A) for the MDD PBMC cohort. E Zoom-in on the proteasome subunit genes that are circled in (A). F Zoom-in on the proteasome subunit genes that are circled in (B). G Zoom-in on the proteasome subunit genes that are circled in (C). H Zoom-in on the proteasome subunit genes that are circled in (D). Note that there is a blue-colored gene in (D) which is circled, UBE2V2, which does not appear in (H) as it does not encode a proteasome subunit.
