Table 1 Gene expression data description.

From: Genome wide analysis implicates upregulation of proteasome pathway in major depressive disorder

GEO accession

Brain region

# MDD samples

# Control samples

Gender distribution

Mean age

Platform

GSE53987 (Lanz et al., 2015)

Hippocampus (HPC)

16a

18

MDD—M = 9, F = 8 Control—M = 9, F = 9

MDD—45.17 Control—48.16

Affymetrix Human Genome U133 Plus 2.0

Striatum (STR)

15b

18

MDD—M = 10, F = 6 Control—M = 10, F = 8

MDD—46.5 Control—48.44

Brodmann area 46 (BA46)

17

19

MDD—M = 9, F = 8 Control—M = 10, F = 9

MDD—45.17 Control—48.05

GSE35978 (Chen et al., 2013)

Parietal cortex (PC)

14

51

MDD—M = 8, F = 6 Control—M = 35, F = 15

MDD—46.07 Control—45.5

Affymetrix Human Gene 1.0 ST Array

Cerebellum (CRBLM)

13

50

MDD—M = 8, F = 5 Control—M = 31, F = 19

MDD—45.38 Control—45.8

GSE92538 (Hagenauer et al., 2018)

The dorsolateral prefrontal cortex (DLPFC)

76

175

MDD—M = 60, F = 16 Control—M = 130, F = 45

MDD—48.6 Control—55.9

Affymetrix GeneChip Human Genome HG-U133 Plus 2 Array

  1. aOne sample was removed from the hippocampus (HPC)-MDD (GSE53987) as it did not pass the quality control (see Fig. S1A). Of 17 samples, we continued to investigate the remaining 16.
  2. bOne sample was removed from the striatum (STR)-MDD (GSE53987) as it did not pass the quality control (see Fig. S1B). Of 16 samples, we continued to investigate the remaining 15.
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