Table 2 Peak voxel locations identified by statistical parametric mapping (version 12) unimodal analysis.

From: Positron emission tomography imaging of serotonin degeneration and beta-amyloid deposition in late-life depression evaluated with multi-modal partial least squares

Brain region

Hemisphere

Atlas coordinates millimeters (MNI) X Y Z

P value

Greater beta-amyloid burden in LLD patients compared to controls

  Middle Frontal Gyrus

Left

−28 50 36

9.0E–04

  Superior Parietal Gyrus

Left

−26 −74 56

5.4E–04

  Precuneus

Left

−4 −80 56

1.3E–03

  Inferior Parietal Gyrus

Left

−26 −72 44

3.3E–04

  Angular Gyrus

Left

−40 −72 48

4.9E–04

  Superior Occipital Gyrus

Left

−26 −72 40

4.0E–04

Lower 5-HTT in LLD patients compared to controls

  Parahippocampal Gyrus

Right

28 −28 −32

2.1E–05

  Superior Temporal Pole

Left

−48 14 −24

7.6E–05

  Inferior Temporal Gyrus

Right

32 2 −44

1.8E–04

  Amygdala

Right

30 −6 −14

4.02E–04

  Amygdala

Left

−26 2 −26

1.9E–03

  Fusiform Gyrus

Right

30 −12 −36

1.3E–05

  Fusiform Gyrus

Left

−28 −12 −32

1.8E–04

  Raphe Pontine

 

−6 −18 −20

6.3E–03

  Raphe Median

 

0 −30 −24

1.3E–02

  Raphe Dorsal

 

4 −28 −12

3.4E–02

  1. Higher Beta-Amyloid (top section) and lower serotonin transporter availability (bottom section) was observed in Late-Life Depressed (LLD) Patients than normal controls, applying the Monte-Carlo Simulation Method (uncorrected P = 0.005).