Table 3 The peak voxel locations of the co-varying spatial patterns of Greater Beta-Amyloid and the Serotonin Transporter (5-HTT) determined by multi-modal Partial Least Squares (mmPLS) for the Normal Controls and Late-Life Depressed Patient Groups.
Brain region | Hemisphere | Atlas coordinates millimeters(MNI) X Y Z | P value |
|---|---|---|---|
Greater beta-amyloid in LLD patients compared to controls | |||
Inferior Temporal Gyrus | Left | −58 −54 −24 | 2.0E–05 |
Precuneus | Right | 6 −78 52 | 7.1E–06 |
Precuneus | Right | 6 −78 56 | 2.2E–05 |
Inferior Parietal Gyrus | Left | −32 −68 44 | 8.6E–04 |
Superior Occipital Gyrus | Right | 22 −78 40 | 1.5E–07 |
Cuneus | Right | 14 −76 36 | 7.8E–06 |
Lower 5-HTT in LLD patients compared to controls | |||
Putamen | Right | 26 −4 −4 | 5.6E–05 |
Putamen | Left | −22 12 −4 | 3.7E–05 |
Thalamus | Right | 14 −28 0 | 9.0E–09 |
Thalamus | Left | −12 −28 4 | 1.4E–05 |
Amygdala | Right | 28 −6 −14 | 2.4E–04 |
Amygdala | Left | −26 −8 −12 | 7.7E–05 |
Hippocampus | Left | −26 −8 −16 | 3.1E–04 |
Pontine Raphe | −2 −26 −20 | 3.1E–07 | |
Dorsal Raphe | 0 −28 −14 | 8.2E–18 | |
Median Raphe | 0 −30 −20 | 1.6E–09 | |
