Fig. 3: Correlation of fat mass with AMPH-induced locomotor activity and AMPH levels in plasma and brain. | Translational Psychiatry

Fig. 3: Correlation of fat mass with AMPH-induced locomotor activity and AMPH levels in plasma and brain.

From: Elevated body fat increases amphetamine accumulation in brain: evidence from genetic and diet-induced forms of adiposity

Fig. 3

A Global, conditional deletion of Tsn during adulthood does not affect the locomotor response to AMPH (2.5 mg/kg, i.p.). B The total locomotor activity induced by AMPH (2.5 mg/kg i.p.) in WT and Tsn KO mice was correlated with % fat mass (r = 0.5571, P = 0.025). n = 8/group. C Plasma AMPH levels (in nmol/mL) (left), and correlation with % fat mass (right; r = 0.744, P = 0.0055). 2.5 mg/kg AMPH was injected i.p. based on body weight. n = 6/group. D Brain AMPH levels (in nmol/g) (left), and correlation with % fat mass (right; r = 0.919, p < 0.0001). 2.5 mg/kg AMPH was injected i.p. based on body weight. n = 6/group. E Plasma and brain AMPH levels when 3.5 mg/kg AMPH was injected i.p. based on lean mass. n = 6/group. F Prior to i.p. injection of 3.5 mg/kg based on lean mass, baseline locomotor activity monitored following saline injection was lower in Tsn KO mice than in WT littermates. G The normalized locomotor response to AMPH shown as a percentage of the baseline level (100%) is comparable between groups. n = 7-8/group. Data are expressed as Mean ± SEM. Statistical significance indicated by asterisks was assessed by Student’s t-test. **p < 0.01.

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