Table 2 Correlation coefficients and statistics for relationships of striatal normalized T2*-weighted signal with biobehavioral variables in the study sample.

From: Biobehavioral correlates of an fMRI index of striatal tissue iron in depressed patients

Neurocognitive index

Striatal normalized T2*-weighted signal

Caudate

Putamen

Nucleus accumbens

Go/NoGo task

Emotion discrimination

āˆ’0.33 (p = 0.001; R2 = 0.11)

āˆ’0.21 (p = 0.036; R2 = 0.04)

āˆ’0.23 (p = 0.020; R2 = 0.05)

General cognitive control

āˆ’0.25 (p = 0.012; R2 = 0.06)

āˆ’0.20 (p = 0.046; R2 = 0.04)

āˆ’0.24 (p = .017; R2 = 0.06)

Emotion regulation

āˆ’0.30 (p = 0.002; R2 = 0.09)

āˆ’0.27 (p = 0.007; R2 = 0.07)

āˆ’0.35 (p < .001; R2 = 0.12)

HPF

Right hippocampus

āˆ’0.26 (p = 0.007; R2 = 0.07)

0.01 (p = 0.959; R2 < 0.001)

0.04 (p = .656; R2 = 0.001)

Left hippocampus

āˆ’0.19 (p = 0.047; R2 = 0.04)

0.03 (p = 0.734; R2 < 0.001)

0.06 (p = 0.557; R2 = 0.004)

  1. Pearson’s r correlation coefficients and associated uncorrected p-values. Bold text indicates correlation is significant at the 0.05 level (2-tailed) after correcting for multiple comparisons; italicized text indicates significant at the 0.05 level in uncorrected analyses only. Go/NoGo task indices coded such that higher values indicate better task performance. HPF = Hippocampal Parachymal Fraction, higher scores indicate greater hippocampal volumetric integrity (less atrophy). For normalized T2*-weighted signal, higher values indicate lower tissue iron concentration.