Table 3 Alterations of brain reactivity to smoking-related cues after the reconsolidation manipulation.

Anatomical region	Coordinates			T	Cluster size (no. of voxels)	Hemisphere
Anatomical region	X	Y	Z		Cluster size (no. of voxels)	Hemisphere
Smoking > neutral cues (propranolol > placebo)
Middle frontal gyrus	−20	−6	37	3.31	53	L
Middle frontal gyrus	42	52	−4	3.15	29	R
Smoking day 3 > smoking day 1 (propranolol > placebo)
Precentral gyrus	32	−14	67	−3.22	50	R
Posterior cingulate	9	−38	12	−2.98	38	R
Cuneus	19	−77	19	−3.04	260	R
Cuneus	−13	−81	26	−3.02	132	L
Middle occipital gyrus	53	−73	1	−2.94	42	R
Superior frontal gyrus	−19	63	15	−2.92	70	L
Postcentral gyrus	31	−35	49	−2.91	52	R

Coordinates are given for the maximally significant voxel in each area, where X defines the lateral placement from the midline (left = negative), Y defines the anteroposterior displacement relative to the anterior commissure (posterior = negative), and Z defines the vertical position relative to the anteroposterior commissural line (down = negative). P values were corrected for multiple comparisons (for the Smoking > neutral cues (propranolol > placebo) on day 3, AlphaSim corrected P < 0.05, cluster size k-threshold of 24 contiguous voxels at uncorrected threshold P < 0.001; for the Smoking day 3 > smoking day 1 (propranolol > placebo), AlphaSim corrected P < 0.05, cluster size k-threshold of 38 contiguous voxels at uncorrected threshold P < 0.001). The coordinates are in Montreal Neurological Institute (MNI) space. The brain regions were automatically identified by NeuroElf software.

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