Table 2 Thirty-seven genomic loci jointly associated with schizophrenia (SCZ) and risk-taking which physical overlapped with loci jointly associated with SCZ and risky behaviours at conjunctional FDR (conjFDR) < 0.05.

From: Characterising the shared genetic determinants of bipolar disorder, schizophrenia and risk-taking

Chr	Min-max BP	Lead SNPs	ConjFDR	Direction of effect	Novel in SCZ	Novel in risk-taking	Mapped genes
1	3,121,877–3,147,290	rs7518852^a	0.028	+	×	Yes	PRDM16^b
1	43,982,527–44,145,130	rs673253	0.018	+	×	Yes	TMEM125, TIE1, MED8^b, PTPRF^b
1	243,281,617–243,645,203	rs10803138	<0.001	+	×	×	SDCCAG8
2	48,176,656–48,707,841	rs138659652	0.019	+	Yes	Yes	MSH6, FBXO11
2	97,593,614–98,332,858	rs115507803	0.038	+	×	Yes	FAHD2B
2	162,798,581–162,891,848	rs6707646	0.007	+/−	×	Yes	SLC4A10
2	225,334,070–225,467,840	rs2047134	0.043	+	×	×	CUL3^b
3	84,841,679–84,961,810	rs1598080	0.018	+	×	×	–
3	86,011,109–86,192,846	rs58783194^a	0.019	+/−	×	Yes	–
4	31,162,143–31,201,229	rs7669969^a	0.022	+	Yes	×	–
4	46,191,375–46,361,545	rs10805144	0.006	+	Yes	×	GABRA2^b
4	66,258,524–66,534,629	rs13124331^a	0.018	+	×	×	EPHA5^b
5	45,411,676–50,161,698	rs13168483	0.007	+	×	Yes	EMB^b
6^c	25,684,606–29,283,672	rs6923811	<0.001	+	×	×	BTN3A2, POM121L2
7	114,940,147–115,113,279	rs4275159^a	0.039	+	Yes	×	–
7	121,952,981–122,008,804	rs988720^a	0.048	+	×	Yes	FEZF1^b, CADPS2^b
8^c	8,088,230–12,203,305	rs9329221	<0.001	+	×	×	MSRA^b, FAM167A
8	38,014,429–38,310,910	rs7845911	0.009	+	×	Yes	LSM1^b, BAG4^b, DDHD2^b, PPAPDC1B^b
8	65,437,964–65,498,165	rs6996198^a	0.039	+	×	×	–
8	143,276,606–143,404,118	rs13281016	<0.001	+	×	Yes	TSNARE1^b
9	26,447,292–27,111,268	rs56409537	0.030	+	×	Yes	–
10	104,546,183–105,165,256	rs12416687	0.002	+/−	×	Yes	ARL3^b, WBP1L^b, BORCS7^b, AS3MT^b
10	106,417,957–106,560,225	rs12761679	0.003	+	×	Yes	SORCS3^b
11	27,581,265–27,742,447	rs6265	0.010	+	×	Yes	BDNF
11	28,375,949–28,580,338	rs12419325	0.014	+	×	Yes	METTL15
12	2,285,731–2,420,526	rs61909095	0.002	+	×	×	CACNA1C^b
12	108,609,634–108,629,780	rs3764002	0.024	+/−	×	×	WSCD2^b
14	78,625,653–78,659,721	rs7153461^a	0.033	+/−	Yes	Yes	–
14	103,849,715–104,537,680	rs6576006	<0.001	+	×	×	KLC1^b, PPP1R13B^b, TDRD9
15	63,460,009–63,547,859	rs6494397	0.050	+/−	Yes	Yes	RPS27L
15	78,714,561–78,926,726	rs12442456	0.009	+/−	×	Yes	IREB2, ADAMTS7^b
15	91,403,674–91,443,059	rs2071382	0.001	+	×	Yes	FES^b, FURIN^b
16	7,324,960–7,417,203	rs8046401	0.031	+	×	Yes	RBFOX1^b
16	71,355,142–71,396,661	rs3826248	0.031	+	×	×	CMTR2, DHODH, DHX38^b
18	53,183,396–53,477,999	rs1382119	<0.001	+	×	×	–
19	30,982,165–31,052,954	rs10421376	0.022	+/−	×	Yes	ZNF536^b
22	41,485,593–42,396,890	rs75843224	0.010	+/−	×	Yes	EP300

Chr chromosome, min–max BP minimum–maximum base pair position, ConjFDR conjFDR value of lead SNP, Direction of effect “+” concordant effect directions of lead SNPs, “+/−” discordant effect direction of lead SNPs on SCZ and risk-taking, Novel SCZ/risk-taking: “Yes” indicates novel loci; Mapped genes—genes mapped to lead SNPs for SCZ and risk-taking.
^aLead SNPs that were also lead SNPs in the risky behaviour loci. For corresponding SCZ and risky behaviour loci please refer to Supplementary Table 2.
^bGenes that were also mapped to lead SNPs for SCZ and risky behaviours.
^cThese loci reside within regions possessing complex LD structure and so gene mapping strategies are not reliable. Mapped genes are provided but should be interpreted with caution.

Back to article page

Table 2 Thirty-seven genomic loci jointly associated with schizophrenia (SCZ) and risk-taking which physical overlapped with loci jointly associated with SCZ and risky behaviours at conjunctional FDR (conjFDR) < 0.05.

Search

Quick links