Table 1 FTD summary statistics discovery and replication analysis for SNPs exceeding genome-wide significance (P < 5e-08) in the discovery analysis.

From: Genome-wide association study of frontotemporal dementia identifies a C9ORF72 haplotype with a median of 12-G4C2 repeats that predisposes to pathological repeat expansions

SNP

Chr

Bp

Closest Gene

ref/alt

% alt

Discovery

Replication

Discovery excluding

Replication excluding

FTD/controls

     

C9ORF72 carriersa

C9ORF72 carriersa

OR

Beta

SE

P

OR

Beta

SE

P

OR

Beta

SE

P

OR

Beta

SE

P

rs76679949

5

168220640

SLIT3

G/C

0.044/0.019

3.75

1.32

0.23

1.40 × 10−8

1.58

0.46

0.34

0.18

NA

NA

NA

NA

NA

NA

NA

NA

rs147211831

9

27436084

C9ORF72

C/A

0.032/0.009

4.96

1.60

0.28

9.18 × 10-9

3.95

1.37

0.42

1.05 × 10−3

1.87

0.62

0.44

0.15

2.33

0.85

0.51

0.09

rs117204439

9

27607973

C9ORF72

T/C

0.039/0.015

4.85

1.58

0.27

5.96 × 10-9

3.21

1.17

0.38

2.04 × 10−3

2.12

0.75

0.39

0.05

1.32

0.27

0.52

0.60

  1. aFor these analyses we excluded FTD patients with pathological C9ORF72 repeat lengths and FTD patients without C9ORF72 data available (N = 28/52 carriers/unknown in discovery, N = 25/58 in replication).
  2. FTD: frontotemporal dementia, SNPs: single nucleotide polymorphisms, Chr: chromosome, Bp: base pair location, ref: reference allele, alt: alternative allele, OR: odds ratio, Se: standard error, NA: not applicable, C9ORF72 chromosome 9 open reading frame 72, SLIT3 Slit Guidance Ligand 3.
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