Table 2 Effects of serum tumor necrosis factor-α level as a binary and continuous variable on the incidence of 12-week and 12-month remission and 24-month relapse.

Exposure	Group	12-Week remission (N = 1086)				12-Month remission (N = 884)				24-Month relapse (N = 710)
		N	No. (%) presence	OR (95% CI)		N	No. (%) presence	OR (95% CI)		N	No. (%) presence	OR (95% CI)
				Unadjusted	Adjusted^a			Unadjusted	Adjusted^a			Unadjusted	Adjusted^a
sTNF-α (binary)	Low	542	261 (48.2)	Reference	Reference	434	329 (75.8)	Reference	Reference	344	112 (32.6)	Reference	Reference
	High	544	229 (42.1)	0.78 (0.62–0.99)^*	0.77 (0.60–1.00)^*	450	296 (65.8)	0.61 (0.46–0.82)^**	0.61 (0.45–0.83)^**	366	189 (51.6)	2.21 (1.63–3.00)^***	2.47 (1.78–3.43)^***
sTNF-α (increasing)	NA	1086	NA	0.75 (0.58–0.97)^*	0.74 (0.57–0.97)^*	884	NA	0.55 (0.41–0.76)^**	0.56 (0.41–0.78)^***	710	NA	1.49 (1.06–2.09)^*	1.56 (1.10–2.21)^*

sTNF-α serum tumor necrosis factor-α.
^aAdjusted for sex, education, marital status, religious observance status, monthly income, presence of melancholic features, presence of atypical features, age at onset, number of depressive episodes, duration of present episode, history of suicide attempts, HADS-A score, and initial antidepressant type.
*P < 0.05.
**P < 0.01.
***P < 0.001.

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