Fig. 2: Association between SLC25A24 methylation and gray matter volume.

Mean gray matter volume (GMV) values in the cluster significantly associated with methylation for p < 0.001, size > 72 voxels were extracted for each participant and then plotted against the average methylation M-value across the DMR on chromosome 1 corresponding to exon 1 of gene SLC25A24. CD participants (red) and TD (blue) participants are differentiated by color. In all clusters there is a negative association between GMV and M value in both CD and TD groups; the difference between groups in the strength of the correlation is not statistically significant at p < 0.05.