Fig. 2: Tcf4 deletion in adult excitatory neurons increases cFos activity. | Translational Psychiatry

Fig. 2: Tcf4 deletion in adult excitatory neurons increases cFos activity.

From: Adult brain neurons require continual expression of the schizophrenia-risk gene Tcf4 for structural and functional integrity

Fig. 2

A, B Quantification of cFos+ cells in GFP+ (SEM+/− 1013) versus GFP− (SEM+/− 3001) CA1 neurons (A) and granule neurons in DG (B), (GFP+ : SEM+/− 146.6), (GFP−: SEM+/− 162.7) of wild-type adult animals (~P60–90). C Representative images of CA1 neurons showing cFos expression. Asterisks depict cFos+GFP+ cells. D Quantification of cFos+ cells in GFP+ versus GFP− CA1 neurons of Tcf4-KO brain, (GFP+ : SEM+/− 1887), (GFP−: SEM+/− 2677). E Quantification of cFos+ cells in GFP+ CA1 neurons from WT and KO brains, (WT: SEM+/− 1013), (KO: SEM+/− 1887) (each dot represents a brain section, ~10 sections per brain were quantified, CA1: 7 WT, 8 KO and DG: 5 WT, 5 KO animals), Wilcoxon test, ****p < 0.0001, error bar represents SEM. Analysis was done 3 weeks post deletion. Scale bar = 10 µm.

Back to article page