Fig. 3: Tcf4 deletion in adult excitatory neuron results in hyperexcitability. | Translational Psychiatry

Fig. 3: Tcf4 deletion in adult excitatory neuron results in hyperexcitability.

From: Adult brain neurons require continual expression of the schizophrenia-risk gene Tcf4 for structural and functional integrity

Fig. 3

A Representative traces for action potential spikes from CA1 neurons of WT and KO brains. B F–I curve for firing (two-way ANOVA, ****p < 0.0001, error bar represents SEM). C–F Cell-intrinsic properties of CA1 neurons. C Resting membrane potential (WT: SEM+/− 0.7, KO: SEM+/− 0.8). D Input resistance traces (WT: SEM+/− 8.3, KO: SEM+/− 8.9) and E quantification. F Rheobase (WT: SEM+/− 10.36, KO: SEM+/− 7). Recording from 27 neurons from WT and 33 neurons from KO brains 2–3 weeks post deletion, representing ~5–6 mice per genotype. Mann–Whitney test: ***p < 0.0005, ****p < 0.0001).

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