Fig. 3: Interaction effect of Drug, Run, and Condition on WM-related BOLD activation in left precuneus (PCU) and left superior parietal lobule (SPL).
From: Methylphenidate modulates interactions of anxiety with cognition
Upper panel: Drug by Run by Condition interaction on WM-related BOLD (3-Back vs. 1-Back contrast) recruitment of the A left PCU and B left SPL. Lower panel: Histograms of the parameter estimates extracted from the A left PCU and B left SPL. Linear mixed-effects models were conducted on the parameter estimates with Drug, Run, and Condition as fixed factors, and Subjects as random factor. Sex and Age were included as covariates. Error bars represent mean ± standard error of the mean. Color bar: warm colors represent WM-related BOLD activation in MPH compared to PLA, while cool colors represent WM-related BOLD activation decrease in MPH compared to PLA. Crosshairs depict the location of the voxel with the peak activation for the given cluster. Wholebrain activations are corrected for multiple comparisons using a cluster-based approach with a voxel-wise bi-sided p-value threshold of p < 0.001 and a minimum cluster size of k = 16 (432 μL), which corresponds to a cluster-level alpha of p < 0.05 using NN2 clustering, where clustered voxels can share faces and edges. For visualization purpose, whole-brain activationsare thresholded here at p = 0.01. *p < 0.05, **p < 0.01, ***p < 0.001.
