Table 1 Significant interaction clusters between Drug (MPH, PLA) and Condition (Safe, Threat) on WM load-related BOLD (3-Back vs. 1-Back) activation in Run-1.

Label	Brodmann area	Side	Peak activation			Number of voxels	Volume (μL)	Mean	SEM	t value
			x	y	z
Drug × Condition in Run-1: MPH vs. PLA in Threat condition
Precuneus	31	L	−11	−50	38	23	621	4367	184	3.65
Posterior cingulate cortex	31	R	5	−23	44	22	594	3831	162	4.33
Superior parietal	7	L	−17	−80	56	21	567	7910	709	3.51
Lateral occipital	18	L	−20	−104	−5	20	540	3652	253	3.54
Lateral orbitofrontal	47	R	35	38	−17	16	432	4452	275	4.31

Degrees of freedom equal 46. Whole-brain activations are corrected for multiple comparisons using a cluster-based approach with a voxel-wise bi-sided p value threshold of p < 0.001 and a minimum cluster size of k = 16 (432 μL), which corresponds to a cluster-level alpha of p < 0.05 using NN2 clustering, where clustered voxels can share faces and edges. LPI means that x increases from Left to Right, y increases from Posterior to Anterior, z increases from Inferior to Superior; Mean and standard error of the mean (SEM) based on absolute value of voxel intensities; correspondences with Brodmann areas are retrieved from the Yale University BioImage Suite.
L left, R right.

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