Fig. 3: Effect size estimates from previously published meta-analyses of RCTs, and from current meta-analysis.

Outcome measure: treatment discontinuation due to any reason Groups: primary benchmark (blue); secondary benchmark (green); and pooled estimates of current meta-analysis (red). Please note that for the comparison of aripiprazole-quetiapine the pooled estimate RWS is only based on two studies. RR relative risk, LCL lower confidence limit, UCL upper confidence limit. Blue The results of individual meta-analyses based on randomized controlled trials’ data considered as primary benchmark. Green The results of individual meta-analyses based on randomized controlled trials’ data considered as secondary benchmark. Red Pooled estimates of current meta-analysis.