Fig. 4: Interaction effect of Diagnosis × BMRM.

BMRM had the different effect on the healthy controls and MDD patients in the functional connectivity between the left posterior parietal thalamus (PPTha) and the bilateral precuneus/posterior Cingulate Gyrus (PCun/PCC). After the BMRM, the MDD patients demonstrated significantly increased FC in left Pptha-bilateral PCun/PCC (turn from negative FC into positive FC), while the HCs demonstrated decreased FC in left PPTha-bilateral PCun/PCC. BMRM body–mind relaxation meditation, L left, R right. *0.01 ≤ p < 0.05, **0.001 ≤ p < 0.01, ***p < 0.00.