Fig. 2: The associations between gene expression, MDD pathogenesis, and fMRI-based brain functional connectome changes. | Translational Psychiatry

Fig. 2: The associations between gene expression, MDD pathogenesis, and fMRI-based brain functional connectome changes.

From: Understanding complex functional wiring patterns in major depressive disorder through brain functional connectome

Fig. 2

(A): Serotonin deficiency hypothesis; (B): Neuroplasticity hypothesis. The gene expression mappings were created according to PET-MR data from Ref. [26], and RNA-seq data from Ref. [25]. The colored brain regions represent higher gene expression levels. The maps of brain functional connectome were manually created according to the data from Ref. [33]. HIP, Hippocampus; AM, Amygdala; ACC, Anterior cingulate cortex; OB: Olfactory bulb; BDNF, Brain-derived neurotrophic factor; 5-HTTP, 5-Hydroxytryptophan; 5-HTT, Serotonin transporter; mPFC, medial prefrontal cortex; AG, Angular gyrus; dACC, Dorsal anterior cingulate cortex; dlPFC, dorsolateral prefrontal cortex.

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