Fig. 4: Predictive biomarkers to differentiate MDD patients with and without suicidal attempts. | Translational Psychiatry

Fig. 4: Predictive biomarkers to differentiate MDD patients with and without suicidal attempts.

From: Understanding complex functional wiring patterns in major depressive disorder through brain functional connectome

Fig. 4

A Functional connectivity (FC) differences in large-scale brain networks. The green line indicated the significant decrease of FC in MDD with suicidal ideation compared to MDD without suicidal attempts. B Increase (red color connections) or decrease (blue color connections) of FC changes in local brain regions for MDD patients with suicidal attempts compared to MDD without suicidal attempts. C Protein and metabolite biomarkers in brain regions and peripheral blood for the differentiation of MDD patients with and without suicidal ideation. Red dots indicated increased expression or concentration in MDD with suicidal ideation compared to MDD without suicidal attempts. Blue dots indicated decreased expression or concentration. SN, Salience network; DMN, Default mode network; FPN, Frontoparietal network; OC, occipital cortex; FFG, fusiform gyrus; MTG, middle temporal gyrus; PHG, parahippocampal gyrus; PCC, posterior cingulate cortex; ACC, anterior cingulate cortex; PFC, Prefrontal cortex; AM, amygdala; DCX, Doublecortin; BDNF, Brain-derived neurotrophic factor, Glu, Glutamate; HSPA1A, Heat shock protein family A member A; DHA, Docosahexaenoic acid; HDL-C, High-density lipoprotein cholesterol; NLR, Neutrophil-to-lymphocyte ratio; TSH, thyroid-stimulating hormone; TgAb, anti-thyroglobulin; TPOAb, thyroid peroxidases antibody; BBB, blood–brain barrier.

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