Table 2 43 Up-regulated proteins in Scz organoids (>0.5 Log2FC, p < 0.05).

From: The proteomic architecture of schizophrenia iPSC-derived cerebral organoids reveals alterations in GWAS and neuronal development factors

Gene Name

Protein Name

Uniprot ID

Log2FC

P-value

SLC2A3

Solute carrier family 2, facilitated glucose transporter member 3

P11169

1.019

0.003

GSTA2

Glutathione S-transferase A2

P09210

0.954

0.030

PODXL

Podocalyxin

O00592-2

0.939

0.000

KRT18

Keratin, type I cytoskeletal 18

P05783

0.884

0.000

AFP

Alpha-fetoprotein

P02771

0.868

0.027

S100A10

Protein S100-A10

P60903

0.861

0.032

AHSG

Alpha-2-HS-glycoprotein

P02765

0.843

0.001

APOM

Apolipoprotein M

O95445-2

0.771

0.002

FGG

Fibrinogen gamma chain

P02679-2

0.768

0.010

FGB

Fibrinogen beta chain

P02675

0.753

0.001

FGA

Fibrinogen alpha chain

P02671-2

0.749

0.008

LIN28A

Protein lin-28 homolog A

Q9H9Z2

0.731

0.001

SLC9A3R1

Na(+)/H( + ) exchange regulatory cofactor NHE-RF1

O14745

0.726

0.001

APOA1

Apolipoprotein A-I

P02647

0.715

0.015

SERPINB9

Serpin B9

P50453

0.712

0.001

SERPINA1

Alpha-1-antitrypsin

P01009

0.705

0.009

APOE

Apolipoprotein E

P02649

0.698

0.006

TF

Serotransferrin

P02787

0.687

0.005

S100A11

Protein S100-A11

P31949

0.685

0.012

APOC3

Apolipoprotein C-III

P02656

0.678

0.027

EPCAM

Epithelial cell adhesion molecule

P16422

0.677

0.041

FN1

Fibronectin

P02751-5

0.650

0.010

APOA4

Apolipoprotein A-IV

P06727

0.634

0.009

PDLIM1

PDZ and LIM domain protein 1

O00151

0.624

0.000

LCP1

Plastin-2

P13796

0.611

0.005

TINAGL1

Tubulointerstitial nephritis antigen-like

Q9GZM7-3

0.591

0.043

TJP2

Tight junction protein ZO-2

Q9UDY2-5

0.591

0.000

SULT2A1

Sulfotransferase 2A1

Q06520

0.588

0.001

HMGCS2

Hydroxymethylglutaryl-CoA synthase, mitochondrial

P54868-2

0.580

0.009

SNAP23

Synaptosomal-associated protein 23

O00161

0.563

0.000

DSP

Desmoplakin

P15924

0.562

0.000

APOB

Apolipoprotein B-100

P04114

0.562

0.015

ELOA

Elongin-A

Q14241

0.560

0.011

UTP14A

U3 small nucleolar RNA-associated protein 14 homolog A

Q9BVJ6-3

0.536

0.029

FKBP11

Peptidyl-prolyl cis-trans isomerase FKBP11

Q9NYL4-2

0.534

0.021

F11R

Junctional adhesion molecule A

Q9Y624

0.534

0.001

ARID3A

AT-rich interactive domain-containing protein 3A

Q99856

0.532

0.001

OSBPL9

Oxysterol-binding protein-related protein 9

Q96SU4-7

0.531

0.001

REEP6

Receptor expression-enhancing protein 6

Q96HR9-2

0.530

0.006

ECHDC1

Ethylmalonyl-CoA decarboxylase

Q9NTX5-2

0.524

0.007

SCD

Acyl-CoA desaturase

O00767

0.509

0.001

METTL7B

Methyltransferase-like protein 7B

Q6UX53

0.505

0.031

DPP4

Dipeptidyl peptidase 4

P27487

0.500

0.031