Fig. 1: fMRI task and modeling.
From: Sub-optimal modulation of gain by the cognitive control system in young adults with early psychosis
A Timing and example stimuli corresponding to neutral and interference conditions. Stimuli were presented for 2.5 s with individual trials organized in blocks of the same condition. Four blocks each of alternating neutral and interference conditions were interspersed by a fixation period. B Brain activation mapped to the cortical surface; canonical CCS regions showed strong and significant activation in the main effect of interference contrast (p < 0.001 uncorrected). The group-by-condition contrast showed increased activation in the left AI in EP participants at a permissive cluster-forming height threshold (p < 0.01 uncorrected). C Node selection for DCM model space: Time series from AI, ACC, and SPC and the visual cortex (VC) were extracted from the left hemisphere to model task-related modulations and stimulus input, respectively. D DCM model space common to all models: stimuli enter directly into VC, interference stimuli were able to modulate lower-order connections in a feedforward manner, with subsequent modulation of higher-order connections between ACC, SPC, and AI connected in a feedforward and feedback manner.
