Fig. 3: In vitro gene expression profiles correspond to in vivo cortical fetal development. | Translational Psychiatry

Fig. 3: In vitro gene expression profiles correspond to in vivo cortical fetal development.

From: A human iPSC-astroglia neurodevelopmental model reveals divergent transcriptomic patterns in schizophrenia

Fig. 3

Transition mapping output showing the degree of overlap between the in vitro transition from day 30 to day 40 (astrocytes) and in vivo transitions between successive periods of cortical development. The maps are colored by −log10(p-value). Strongest overlap was observed with in vivo transitions to period 7 (24 PCW to 38 PCW), involving mostly downregulated genes in both in vitro and in vivo transitions. PCW post conception week, M month, Y year.

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