Fig. 3: DE proteins and microbiota-related coexpression modules.

A Matrix summarizes enrichment of DE proteins in coexpression modules for each tissue. The significance of enrichment (−log10 (BH-corrected p value), one-sided Fisher’s exact test) is scaled by color intensity. BH-corrected **p < 0.01, ***p < 0.001. B Circos plot shows overlapped proteins in modules from PFC, OB, liver, cecum, and serum. The outside arcs of circus plot represent each module, and the inside arcs represent the proteins in each module. Dark orange represents the proteins that appear in multiple module and light orange represents proteins that are unique to that module. Purple links indicate the overlapped proteins among modules, and blue links indicate the functional overlap among modules. C GO enrichment analysis for 18 microbiota-related modules. The heatmap cells are colored by the p values of representative GO terms.