Fig. 3: The effect of controlling for macrostructural volume on the percentage of white matter (WM) skeleton that displays significant group differences.
From: Opposing white matter microstructure abnormalities in 22q11.2 deletion and duplication carriers
Comparing 22q11.2 deletion carriers (22q-del) and healthy controls (HC) (Panel A) shows that without controlling for macrostructural volume (left column), 22q-del displays significant differences in all microstructural parameters (FAt, FW, F1, F2, Fiso). When controlling for relative cerebrospinal fluid (CSF) volume (middle column) or relative WM volume (right column), these group differences disappear or diminish. Comparing 22q11.2 duplication carriers (22q-dup) and HC (Panel B) shows that the percentage of skeleton voxels with significant findings (left column) remain similar when controlling for CSF volume (middle row) or WM volume (right row).
