Fig. 4: Summary of overall results.
From: Opposing white matter microstructure abnormalities in 22q11.2 deletion and duplication carriers
When not correcting for macroscopic volumes, 22q11.2 deletion (22q-del) and 22q11.2 duplication carriers (22q-dup) show opposite patterns of white matter (WM) changes compared with healthy controls (HC). Significant macrostructural changes (lower WM/ higher cerebrospinal (CSF) volume) were found in 22q-del but not in 22q-dup. When controlling for macrostructural effects, microstructural changes are no longer significant in 22q-del but remain significant in 22q-dup. Taken together, these results do not support gene dosage as a direct cause for micro- or macrostructural differences in 22q-del and 22q-dup.
