Table 3 FAT and FW group comparisons *.

From: Opposing white matter microstructure abnormalities in 22q11.2 deletion and duplication carriers

 

Covariates: age, sex, motion

Covariates: age, sex, motion, CSF volume

Covariates: age, sex, motion, WM volume

FAT

   

F-test

45% of the WM skeleton

24% of the WM skeleton

27% of the WM skeleton

 22q-del versus HC

22q-del > HC: 24%

22q-del > HC: –

22q-del > HC: 1,5%

22q-del < HC: –

22q-del < HC: –

22q-del < HC: –

 22q-dup versus HC

22q-dup > HC: –

22q-dup > HC: –

22q-dup > HC: –

22q-dup < HC: 8%

22q-dup < HC: 23%

22q-dup < HC: 7%

 22q-del versus 22q-dup

22q-del > 22q-dup: 54%

22q-del > 22q-dup: 40%

22q-del > 22q-dup: 35%

22q-del < 22q-dup: –

22q-del < 22q-dup: –

22q-del < 22q-dup: –

FW

   

F-test

72% of the WM skeleton

63% of the WM skeleton

55% of the WM skeleton

 22q-del versus HC

22q-del > HC: –

22q-del > HC: –

22q-del > HC: –

22q-del < HC: 49%

22q-del < HC: 3%

22q-del < HC: –

 22q-dup versus HC

22q-dup > HC: 59%

22q-dup > HC: 60%

22q-dup > HC: 60%

22q-dup < HC: –

22q-dup < HC: –

22q-dup < HC: –

 22q-del versus 22q-dup

22q-del > 22q-dup: –

22q-del > 22q-dup: –

22q-del > 22q-dup: –

22q-del < 22q-dup: 76%

22q-del < 22q-dup: 69%

22q-del < 22q-dup: 60%

  1. CSF cerebrospinal fluid, FAT fractional anisotropy of cellular tissue, FW extracellular free-water, HC healthy controls, WM white matter, 22q-del 22q11.2 deletion carriers, 22q-dup 22q11.2 duplication carriers.
  2. *All group comparisons were conducted utilizing non-parametric voxel-wise permutation tests for each voxel on the WM skeleton in FSL’s Randomize [81]. We tested data against a null distribution generated with 5000 permutations for each contrast using threshold-free cluster enhancement [82] and family wise error correction at a significance level of p < 0.05.
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