Table 4 F1, F2, and Fiso group comparisons*.

From: Opposing white matter microstructure abnormalities in 22q11.2 deletion and duplication carriers

 

Covariates: age, sex, motion

Covariates: age, sex, motion, CSF volume

Covariates: age, sex, motion, WM volume

F1

   

F-test

36% of the WM skeleton

32% of the WM skeleton

14% of the WM skeleton

 22q-del versus HC

22q-del > HC: 8%

22q-del > HC: –

22q-del > HC: –

22q-del < HC: –

22q-del < HC: –

22q-del < HC: –

 22q-dup versus HC

22q-dup > HC: –

22q-dup > HC: –

22q-dup > HC: –

22q-dup < HC: 26%

22q-dup < HC: 29%

22q-dup < HC: 21%

 22q-del versus 22q-dup

22q-del > 22q-dup: 43%

22q-del > 22q-dup: 31%

22q-del > 22q-dup: 21%

22q-del < 22q-dup: –

22q-del < 22q-dup: –

22q-del < 22q-dup: –

F2

   

F-test

40% of the WM skeleton

26% of the WM skeleton

23% of the WM skeleton

 22q-del versus HC

22q-del > HC: 28%

22q-del > HC: 12%

22q-del > HC: 2%

22q-del < HC: –

22q-del < HC: –

22q-del < HC: –

 22q-dup versus HC

22q-dup > HC: –

22q-dup > HC: –

22q-dup > HC: –

22q-dup < HC: 21%

22q-dup < HC: 21%

22q-dup < HC: 19%

 22q-del versus 22q-dup

22q-del > 22q-dup: 46%

22q-del > 22q-dup: 34%

22q-del > 22q-dup: 28%

22q-del < 22q-dup: –

22q-del < 22q-dup: –

22q-del < 22q-dup: –

Fiso

   

F-test

66% of the WM skeleton

55% of the WM skeleton

50% of the WM skeleton

 22q-del versus HC

22q-del > HC: –

22q-del > HC: –

22q-del > HC: –

22q-del < HC: 49%

22q-del < HC: 18%

22q-del < HC: 12%

 22q-dup versus HC

22q-dup > HC: 48%

22q-dup > HC: 52%

22q-dup > HC: 47%

22q-dup < HC: –

22q-dup < HC: –

22q-dup < HC: –

 22q-del versus 22q-dup

22q-del > 22q-dup: –

22q-del > 22q-dup: –

22q-del > 22q-dup: –

22q-del < 22q-dup: 72%

22q-del < 22q-dup: 64%

22q-del < 22q-dup: 47%

  1. CSF cerebrospinal fluid, F1 fractional volume of primary fiber population, F2 fractional volume of secondary fiber population, Fiso fractional volume of the isotropic compartment, HC healthy controls, WM white matter, 22q-del 22q11.2 deletion carriers, 22q-dup 22q11.2 duplication carriers.
  2. *All group comparisons were conducted utilizing non-parametric voxel-wise permutation tests for each voxel on the WM skeleton in FSL’s Randomize [81]. We tested data against a null distribution generated with 5000 permutations for each contrast using threshold-free cluster enhancement [82] and family wise error correction at a significance level of p < 0.05.
Back to article page