Table 2 Association between hippocampal volume and the polygenic scores for hippocampal volume as computed from the Hibar et al. [22] and the Hibar et al. [26] GWAS at the maximizing thresholds both in the individual cohorts and the meta-analysis across cohorts.

From: Trauma and posttraumatic stress disorder modulate polygenic predictors of hippocampal and amygdala volume

Cohort

GWAS

Threshold

Beta

p-value

Meta-analysis

2015

0.0021

0.050

6.17E−08

 

2017

0.8891

0.087

1.10E−20

MIRE

2015

0.0001

0.14

0.037

 

2017

0.0001

0.12

0.073

PGC-PTSD

2015

0.0001

0.054

0.24

 

2017

0.0041

0.13

0.0049

TRAC

2015

0.0361

0.21

0.0033

 

2017

0.6591

0.22

0.0018

UKBB

2015

0.1171

0.073

1.25E−13

 

2017

0.1331

0.089

2.65E−19

VETS

2015

0.3021

0.10

0.044

 

2017

0.6691

0.089

0.076

  1. PGC-PTSD Psychiatric Genetics Consortium-Posttraumatic Stress Disorder, TRAC Translational Research Center for TBI and Stress, VETS Vietnam Era Twin Study of Aging, MIRE Duke University and VA Mid-Atlantic Mental Illness Research Education and Clinical Center, UKBB United Kingdom BioBank.