Table 2 Association between hippocampal volume and the polygenic scores for hippocampal volume as computed from the Hibar et al. [22] and the Hibar et al. [26] GWAS at the maximizing thresholds both in the individual cohorts and the meta-analysis across cohorts.
Cohort | GWAS | Threshold | Beta | p-value |
|---|---|---|---|---|
Meta-analysis | 2015 | 0.0021 | 0.050 | 6.17E−08 |
2017 | 0.8891 | 0.087 | 1.10E−20 | |
MIRE | 2015 | 0.0001 | 0.14 | 0.037 |
2017 | 0.0001 | 0.12 | 0.073 | |
PGC-PTSD | 2015 | 0.0001 | 0.054 | 0.24 |
2017 | 0.0041 | 0.13 | 0.0049 | |
TRAC | 2015 | 0.0361 | 0.21 | 0.0033 |
2017 | 0.6591 | 0.22 | 0.0018 | |
UKBB | 2015 | 0.1171 | 0.073 | 1.25E−13 |
2017 | 0.1331 | 0.089 | 2.65E−19 | |
VETS | 2015 | 0.3021 | 0.10 | 0.044 |
2017 | 0.6691 | 0.089 | 0.076 |