Fig. 2: Transcriptional signatures of ketamine responders vs. non-responders at baseline. | Translational Psychiatry

Fig. 2: Transcriptional signatures of ketamine responders vs. non-responders at baseline.

From: Whole blood transcriptional signatures associated with rapid antidepressant response to ketamine in patients with treatment resistant depression

Fig. 2

a Volcano plots showing significantly (p < 0.05, fold change > or <1.3) differentially expressed genes (DEG) [red = upregulated and blue = downregulated]. Gene names are indicated for the top 25 differentially expressed protein-coding genes. b Ingenuity Pathway Analysis (IPA) identified two biological pathways (red = activation) enriched at baseline in responders vs. non-responders. c DEGs within each pathway. d Predicted upstream regulators identified by IPA (red indicates predicted activation, blue indicates predicted inhibition).

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