Table 2 Main results of the analysis of variance using polygenic risk score (PRS) for schizophrenia (SZ-PRS) and bipolar disorder (BD-PRS) across the eight studied groups (Table S2 provides the full list of pairwise tests).

From: Polygenic risk scores across the extended psychosis spectrum

Measure

ANOVA

Means (z-score)

Significant post hoc tests

 

Sum of squares

df

Mean square

F

p

Group

Mean

SD

Pairwise contrast

Beta

SE

Adjusted p

SZ-PRS

61.01

7

8.716

9.300

2.52 × 10−11

CTRL

−0.214

0.988

CTRL–SZA

−0.537

0.121

2.53 × 10−4

SCHIZ L

−0.222

0.947

CTRL–SZ

−0.474

0.076

1.65 × 10−8

SCHIZ H

−0.323

1.018

SCHIZ L–SZA

−0.534

0.146

0.007

RISK

0.055

0.88

SCHIZ L–SZ

−0.471

0.109

4.50 × 10−4

BD I

0.036

0.986

SCHIZ H–BD I

−0.388

0.112

0.015

BD II

−0.07

0.977

SCHIZ H–SZA

−0.683

0.146

9.18 × 10−5

SZA

0.253

0.958

SCHIZ H–SZ

−0.621

0.110

5.73 × 10−7

SZ

0.243

1.012

BD I–SZ

−0.233

0.072

0.034

   

BD II–SZ

−0.362

0.112

0.034

   

CTRL–BD I

−0.242

0.078

0.054#

   

SCHIZ H–RISK

−0.394

0.129

0.064#

Residuals

1466.67

1565

0.937

         

BD-PRS

76.51

7

10.930

11.709

1.37 × 10−14

CTRL

−0.268

0.943

CTRL–RISK

−0.412

0.113

0.007

SCHIZ L

−0.222

0.993

CTRL–BD I

−0.558

0.078

2.86 × 10−11

SCHIZ H

−0.181

0.905

CTRL–BD II

−0.461

0.115

0.002

RISK

0.230

0.905

CTRL–SZA

−0.572

0.12

5.99 × 10−5

BD I

0.276

0.984

SCHIZ L–RISK

−0.404

0.128

0.045

BD II

0.206

0.96

SCHIZ L–BD I

−0.550

0.111

2.11 × 10−5

SZA

0.213

0.971

SCHIZ L–BD II

−0.453

0.140

0.033

SZ

−0.095

1.041

SCHIZ L–SZA

−0.565

0.145

0.003

   

SCHIZ H–BD I

−0.547

0.112

3.10 × 10−5

   

SCHIZ H–BD II

−0.450

0.140

0.038

   

SCHIZ H–SZA

−0.561

0.146

0.004

   

BD I–SZ

0.351

0.072

3.12 × 10−5

   

SZA–SZ

0.365

0.117

0.050#

   

SCHIZ H–RISK

−0.401

0.129

0.053#

Residuals

1460.92

1565

0.933

         
  1. Note: The analyses accounted for age, sex, and the first five genetic ancestry principal components, and statistical significance is indicated by Bonferroni-adjusted p values.
  2. Adjusted p Bonferroni adjusted p value, beta beta coefficient, df degrees of freedom, SE standard error, BD I bipolar I disorder, BD II bipolar II disorder, CTRL controls, RISK at-risk state for psychosis, SCHIZ L lower schizotypy, SCHIZ H higher schizotypy, SZA schizoaffective disorder, SZ schizophrenia.
  3. #Trend toward statistical significance.
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