Table 2 Gene-based analysis of association of low-frequency variants and DSST scores.

From: Association of low-frequency and rare coding variants with information processing speed

Ancestry

Test

Gene

Chr

CMAF (%)

Betaa (SE)

Betab (SE)

Variants (N)

Z-Score

p value1

Z-Score

p value2

Genome-Wide

EA

T01

RNF19A

8q22.2

0.18

–

–

–

−4.75

2.01 × 10−6

−4.51

6.31 × 10−6

Suggestive

EA

T5/T1

OR51A7

11p15.4

0.25

–

–

–

−4.42

9.76 × 10−6

−4.66

3.13 × 10−6

Suggestive

AA

T01

SLC22A7

6p21.1

0.078

17.74 (3.97)

15.79 (3.37)

2

–

8.12 × 10−6

–

2.78 × 10−6

  1. DSST Digit-Symbol Substitution Test, EA European ancestry, AA African ancestry, Chr chromosome, CMAF cumulative minor allele frequency of variants identified in burden test, SE standard error, N number of variants contributing to burden test, Z-score summary value for sample size weighted meta-analysis.
  2. 1p value adjusted for age and gender; 2p value adjusted for age, gender, and educational attainment.
  3. aBeta beta coefficient for model adjusted for age and gender.
  4. bBeta beta coefficient for model adjusted for age, gender, and educational attainment.
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