Fig. 1: Large subgroups in schizophrenia and bipolar disorder displayed high inflammation. | Translational Psychiatry

Fig. 1: Large subgroups in schizophrenia and bipolar disorder displayed high inflammation.

From: A schizophrenia subgroup with elevated inflammation displays reduced microglia, increased peripheral immune cell and altered neurogenesis marker gene expression in the subependymal zone

Fig. 1

A Two-step cluster analysis of inflammatory gene expression revealed ‘high inflammation’ (total n = 23, darker shade) and ‘low inflammation’ (total n = 65, lighter shade) subgroups across the cohort. The proportion of cases in high or low inflammation subgroups significantly differed by diagnosis, with a greater proportion of schizophrenia and bipolar disorder cases in the high inflammation subgroup than controls. B All genes, except IL6ST, had significantly greater expression in high inflammation schizophrenia and bipolar disorder subgroups compared to all low inflammation subgroups. Grey box indicates the genes used in the final cluster analysis. Data are plotted relative to the mean of the low inflammation control group (100%) ± standard error of the mean. BPD bipolar disorder, CTRL control, High high inflammation, Low low inflammation, SCZ schizophrenia. *p < 0.05, **p < 0.01, ***p < 0.001.

Back to article page