Fig. 3: Peripheral immune cell marker and immune cell recruitment mRNA expression was increased in high inflammation subgroups in psychiatric disorders. | Translational Psychiatry

Fig. 3: Peripheral immune cell marker and immune cell recruitment mRNA expression was increased in high inflammation subgroups in psychiatric disorders.

From: A schizophrenia subgroup with elevated inflammation displays reduced microglia, increased peripheral immune cell and altered neurogenesis marker gene expression in the subependymal zone

Fig. 3

A–D Peripheral immune cell markers had increased expression in the high inflammation schizophrenia group compared to low inflammation schizophrenia and controls. CD163 (A) and CD14 mRNAs (C) were also increased in high compared to low inflammation bipolar disorder. E ICAM1 mRNA was increased in high compared to low inflammation groups within diagnostic groups and compared to low inflammation controls. Data are plotted relative to the mean of the low inflammation control group (100%) ± standard error of the mean. High inflammation controls are displayed as grey points but were not used in statistical analyses. BPD bipolar disorder, CTRL control, High high inflammation, Low low inflammation, SCZ schizophrenia. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

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