Fig. 5: Neurogenesis marker gene expression was predominantly altered in the high inflammation subgroup in schizophrenia. | Translational Psychiatry

Fig. 5: Neurogenesis marker gene expression was predominantly altered in the high inflammation subgroup in schizophrenia.

From: A schizophrenia subgroup with elevated inflammation displays reduced microglia, increased peripheral immune cell and altered neurogenesis marker gene expression in the subependymal zone

Fig. 5

A GFAPD mRNA was reduced in low inflammation schizophrenia compared to both high inflammation schizophrenia and low inflammation controls. B MKI67 mRNA did not differ by inflammatory subgroup. C ASCL1 mRNA was reduced in high inflammation schizophrenia compared to low inflammation controls. D DLX6-AS1 mRNA was decreased in high inflammation schizophrenia compared to low inflammation controls as well as in high inflammation bipolar disorder compared to both low inflammation bipolar disorder and controls. E DCX mRNA was decreased in high inflammation schizophrenia compared to both low inflammation schizophrenia and low inflammation controls. Data are plotted relative to the mean of the low inflammation control group (100%) ± standard error of the mean. High inflammation controls are displayed as grey points but were not used in statistical analyses. BPD bipolar disorder, CTRL control, High high inflammation, Low low inflammation, SCZ schizophrenia. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

Back to article page