Table 3 First-episode psychosis patients (FEP) vs. multi-episode psychosis patients (MEP).

From: Cerebrospinal fluid abnormalities in first- and multi-episode schizophrenia-spectrum disorders: impact of clinical and demographical variables

Variables

N

First-episode

Multi-episode

t/Χ²

df

p

Demographics

Age at time of LP

128/192

34.43 ± 15.00

40.05 ± 15.67

−3.195

318

0.002a

Duration of illness (months)

95/180

11.17 ± 27.06

103.31 ± 112.82

−10.405

215.28

<0.001a

Age at onset of disease (years)

112/181

34.34 ± 14.89

31.52 ± 12.91

1.653

210.22

0.100a

Gender (f/m)

320

49/79

87/105

1.554

1

0.213b

CSF parameter

Protein level (mg/dl)

127/190

36.77 ± 13.12

40.41 ± 16.29

−2.196

304.1

0.029a

Protein level elevated (yes/no)

317

19/108

45/145

3.595

1

0.058b

Albumin ratio

127/192

5.41 ± 2.28

6.19 ± 2.83

−2.745

304.57

0.006a

Albumin ratio elevated (yes/no)

319

32/95

64/128

2.405

1

0.121b

White blood cell count (cells/µl)

127/191

1.32 ± 1.37

1.70 ± 2.02

−2.017

315.87

0.044*

Pleocytosis (> 4/µl)

318

6/121

13/178

0.589

1

0.443b

Pleocytosis (> 5/µl)

318

3/124

8/183

  

0.536c

Pleocytosis (> 6/µl)

318

1/126

6/185

  

0.250c

OCB (yes/no)

318

38/89

77/114

3.569

1

0.059b

OCB intrathecal synthesis (yes/no)

115

12/26

24/53

0.002

1

0.964b

  1. aIndependent t test.
  2. bX² test.
  3. cFisher’s exact test (two-sided) was used in case n < 5 in a 2 × 2 table.
  4. CSF cerebrospinal fluid, f female, LP lumbar puncture, m male, OCB oligoclonal bands.