Table 5 Documented treatment with clozapine lifetime.

From: Cerebrospinal fluid abnormalities in first- and multi-episode schizophrenia-spectrum disorders: impact of clinical and demographical variables

Variables

N

Clozapine treatment lifetime (N = 68)

No documented clozapine treatment lifetime (N = 263)

t/Χ²

df

p

Demographics

Age at time of LP

68/263

38.75 ± 17.45

37.40 ± 15.08

0.586

94.48

0.559a

Duration of illness (months)

66/211

123.53 ± 135.98

55.82 ± 83.74

3.83

80.98

<0.001a

Age at onset of disease (years)

65/229

28.94 ± 12.63

33.64 ± 13.87

−2.456

292

0.015a

Gender (f/m)

331

29/39

114/149

0.011

1

0.917b

CSF parameter

Protein level (mg/dl)

328

41.45(N = 68)± 17.26

38.13(N = 260)± 14.30

1.63

326

0.104a

Protein level elevated (yes/no)

328

19/49

46/214

3.56

1

0.059b

Albumin ratio

330

6.37(N = 68) ± 3.05

5.72(N = 262) ± 2.48

1.81

328

0.071a

Albumin ratio elevated (yes/no)

330

22/46

75/187

0.361

1

0.548b

White blood cell count (cells/µl)

329

1.72(N = 68) ±1.91

1.52(N = 261)±1.77

0.839

327

0.402a

Pleocytosis (> 4/µl) (yes/no)

329

7/61

13/248

2.667

1

0.102b

Pleocytosis (> 5/µl) (yes/no)

329

4/64

8/253

  

0.279c

Pleocytosis (> 6/µl) (yes/no)

329

3/65

5/256

  

0.369c

OCB (yes/no)

329

24/44

98/163

0.117

1

0.732b

OCB intrathecal synthesis (yes/no)

122

10/14

29/69

1.292

1

0.256b

  1. aIndependent t test.
  2. bX² test.
  3. cFisher’s exact test (two-sided) was used in case n < 5 in a 2 × 2 table.
  4. CSF cerebrospinal fluid, f female, LP lumbar puncture, m male, OCB oligoclonal bands.