Table 1 Correlations between age and pre-surgery DNAm in the TNF gene.

From: DNA methylation in the inflammatory genes after neurosurgery and diagnostic ability of post-operative delirium

		EPIC		EPIC		EPIC		pyrosequencing		pyrosequencing		pyrosequencing
		all		POD		non-POD		all		POD		non-POD
		N = 37		N = 10		N = 27		N = 27		N = 7		N = 20
cg	location	r	p	r	p	r	p	r	p	r	p	r	p
	chr6: 31542460							−0.43	0.03	−0.57	0.18	−0.29	0.22
cg08639424	chr6: 31542556	−0.18	0.28	−0.21	0.56	−0.17	0.39
cg19978379	chr6: 31542671	0.28	0.10	0.01	0.98	0.40	0.04
cg24452282	chr6: 31542741	0.22	0.18	0.14	0.70	0.27	0.17
	chr6: 31543170							−0.47	0.01	−0.62	0.14	−0.42	0.06
	chr6: 31543176							−0.46	0.02	−0.70	0.08	−0.41	0.07
	chr6: 31543178							−0.54	0.004	−0.62	0.14	−0.39	0.09
	chr6: 31543193							−0.51	0.006	−0.56	0.19	−0.49	0.028
cg21370522	chr6: 31543219	−0.17	0.32	−0.03	0.93	−0.29	0.15	−0.49	0.009	−0.57	0.18	−0.47	0.035
cg19648923	chr6: 31543266	−0.40	0.01	−0.32	0.37	−0.44	0.02	−0.38	0.051	−0.54	0.22	−0.31	0.18
cg01569083	chr6: 31543290	−0.39	0.02	−0.29	0.41	−0.47	0.01	−0.53	0.005	−0.64	0.12	−0.46	0.040
cg03037030	chr6: 31543300	−0.47	0.004	−0.43	0.21	−0.47	0.01	−0.40	0.04	−0.53	0.23	−0.37	0.11
	chr6: 31543430							−0.48	0.01	−0.41	0.36	−0.41	0.08
	chr6: 31543487							−0.45	0.02	−0.33	0.46	−0.42	0.07
cg12681001	chr6: 31543541	−0.52	*0.0009	−0.42	0.22	−0.58	0.0014	−0.38	0.049	−0.13	0.78	−0.37	0.10
cg21222743	chr6: 31543546	−0.60	*<0.0001	−0.66	0.04	−0.57	0.0018	−0.42	0.03	−0.20	0.67	−0.42	0.07
cg10717214	chr6: 31543558	−0.58	*0.0002	−0.70	0.02	−0.54	0.0038	−0.02	0.94	0.11	0.83	−0.07	0.79
cg04425624	chr6: 31543566	−0.50	0.0016	−0.62	0.06	−0.50	0.0081	−0.24	0.26	−0.22	0.68	−0.30	0.24
cg21467614	chr6: 31543638	−0.64	*<0.0001	−0.70	0.03	−0.66	*0.0002
cg08553327	chr6: 31543647	−0.57	*0.0003	−0.63	0.05	−0.56	0.0023
cg26729380	chr6: 31543655	−0.62	*<0.0001	−0.71	0.02	−0.59	0.0013
cg10650821	chr6: 31543686	−0.46	0.0039	−0.37	0.29	−0.52	0.0056
	chr6: 31544695							−0.03	0.89	0.11	0.82	0.01	0.98
	chr6: 31544752							−0.12	0.56	−0.04	0.92	−0.24	0.31
	chr6: 31544800							−0.05	0.80	−0.20	0.67	−0.18	0.46
	chr6: 31544822							−0.05	0.82	0.13	0.78	−0.24	0.31
	chr6: 31544848							−0.24	0.22	−0.76	0.047	−0.34	0.14
cg01360627	chr6: 31544931	−0.09	0.60	−0.11	0.75	−0.08	0.70	−0.11	0.60	−0.19	0.68	−0.29	0.22
cg23384708	chr6: 31544934	−0.01	0.96	0.06	0.87	−0.27	0.17	−0.01	0.96	−0.03	0.95	−0.24	0.31
cg20477259	chr6: 31544960	0.01	0.97	0.15	0.69	−0.13	0.53	0.03	0.89	0.01	0.98	−0.03	0.89
	chr6: 31545253							−0.02	0.92	0.52	0.23	−0.20	0.39
	chr6: 31545258							−0.11	0.58	0.27	0.56	−0.36	0.11
cg15989608	chr6: 31545322	−0.21	0.20	−0.31	0.38	−0.25	0.21	−0.11	0.57	0.25	0.59	−0.40	0.08
	chr6: 31545267							−0.09	0.66	0.13	0.80	−0.38	0.11
cg26736341	chr6: 31545343	−0.18	0.28	−0.24	0.51	−0.26	0.20	0.28	0.17	0.51	0.30	0.28	0.24
	chr6: 31545432							0.10	0.63	0.23	0.62	−0.12	0.62
cg04472685	chr6: 31545474	−0.11	0.53	−0.15	0.68	−0.14	0.49	−0.32	0.15	0.18	0.77	−0.46	0.06
cg19124225	chr6: 31545836	−0.08	0.63	0.02	0.96	0.01	0.97
cg02137984	chr6: 31545899	−0.34	0.04	−0.40	0.25	−0.21	0.29
cg06825478	chr6: 31546068	0.10	0.54	−0.17	0.63	0.14	0.48	0.21	0.29	0.44	0.32	0.15	0.52
	chr6: 31546086							0.00	0.99	0.22	0.64	−0.10	0.67

underline nominal significance (P < 0.05).
*Significant after correction for multiple testing level (EPIC; P < 0.05/52 = 0.00096, pyrosequencing; P < 0.05/32 = 0.00156).

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Table 1 Correlations between age and pre-surgery DNAm in the TNF gene.

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