Table 3 Changes of DNAm in TNF gene after neurosurgery.

From: DNA methylation in the inflammatory genes after neurosurgery and diagnostic ability of post-operative delirium

		EPIC				EPIC				EPIC				pyrosequencing				pyrosequencing				pyrosequencing
		N = 37				N = 10				N = 27				N = 27				N = 7				N = 20
		all				POD				non-POD				all				POD				non-POD
		pre	post		paired-t	pre	post		paired-t	pre	post		paired-t	pre	post		paired-t	pre	post		paired-t	pre	post		paired-t
cg	location	mean	mean	diff	p value	mean	mean	diff	p value	mean	mean	diff	p value	mean	mean	diff	p value	mean	mean	diff	p value	mean	mean	diff	p value
	chr6: 31542460													74.0	78.1	4.1	*0.0004	72.7	78.1	5.4	0.10	74.5	78.1	3.6	0.00158
cg08639424	chr6: 31542556	77.9	86.2	8.3	*<0.0001	77.7	88.0	10.3	0.001	78.0	85.5	7.5	*<0.0001
cg19978379	chr6: 31542671	71.8	81.0	9.2	*<0.0001	73.0	81.9	8.9	0.001	71.3	80.6	9.3	*<0.0001
cg24452282	chr6: 31542741	73.5	84.5	11.1	*<0.0001	73.8	86.9	13.1	*<0.0001	73.3	83.6	10.3	*<0.0001
	chr6: 31543170													7.0	5.7	−1.4	0.02	6.5	6.4	−0.1	0.94	7.2	5.4	−1.8	0.007
	chr6: 31543176													8.9	7.5	−1.3	0.03	8.0	7.5	−0.5	0.57	9.2	7.6	−1.6	0.04
	chr6: 31543178													3.3	2.6	−0.7	0.15	2.0	2.3	0.3	0.84	3.8	2.7	−1.1	0.03
	chr6: 31543193													5.2	4.0	−1.3	0.01	4.6	3.5	−1.1	0.32	5.5	4.1	−1.3	0.02
cg21370522	chr6: 31543219	13.2	14.1	0.9	0.34	13.6	14.4	0.8	0.64	13.0	13.9	1.0	0.41	4.2	3.5	−0.8	0.02	3.8	3.6	−0.2	0.75	4.4	3.4	−0.9	0.008
cg19648923	chr6: 31543266	10.6	8.1	−2.4	*0.0002	10.3	7.8	−2.5	0.005	10.6	8.2	−2.4	0.004	2.9	2.3	−0.6	0.02	2.7	2.4	−0.3	0.63	3.0	2.3	−0.8	0.02
cg01569083	chr6: 31543290	18.9	17.4	−1.5	0.14	19.0	16.8	−2.2	0.12	18.8	17.7	−1.2	0.36	3.3	2.6	−0.7	0.02	2.9	2.5	−0.4	0.55	3.5	2.7	−0.8	0.02
cg03037030	chr6: 31543300	6.3	4.9	−1.4	0.008	5.6	4.5	−1.1	0.06	6.6	5.0	−1.6	0.03	9.0	7.8	−1.2	0.02	8.5	7.6	−0.9	0.44	9.1	7.8	−1.3	0.02
	chr6: 31543430													1.9	2.0	0.0	0.97	1.5	1.9	0.4	0.42	2.1	2.0	−0.1	0.55
	chr6: 31543487													6.3	5.3	−1.0	0.046	5.3	4.9	−0.4	0.60	6.6	5.4	−1.2	0.06
cg12681001	chr6: 31543541	9.0	7.3	−1.8	0.002	8.8	6.7	−2.0	0.04	9.1	7.5	−1.7	0.02	10.4	9.1	−1.3	0.052	9.1	9.5	0.4	0.67	10.9	9.0	−1.9	0.02
cg21222743	chr6: 31543546	6.6	4.0	−2.6	*<0.0001	5.8	3.4	−2.4	0.003	6.9	4.2	−2.7	*0.0002	8.8	7.3	−1.5	0.01	7.7	7.1	−0.6	0.57	9.2	7.4	−1.8	0.01
cg10717214	chr6: 31543558	9.3	6.4	−2.9	*<0.0001	8.3	6.0	−2.2	0.002	9.7	6.5	−3.1	*0.0002	33.5	32.7	−0.8	0.47	33.6	35.0	1.4	0.48	33.5	32.0	−1.5	0.34
cg04425624	chr6: 31543566	17.4	13.1	−4.3	*0.0003	17.2	12.0	−5.2	0.01	17.5	13.5	−3.9	0.006	21.2	20.8	−0.4	0.86	20.8	21.6	0.8	0.57	21.3	20.5	−0.8	0.62
cg21467614	chr6: 31543638	17.7	14.7	−3.0	*<0.0001	17.1	14.1	−3.0	*0.0005	17.9	15.0	−2.9	0.003
cg08553327	chr6: 31543647	16.5	13.1	−3.4	0.001	15.4	11.6	−3.8	0.003	16.9	13.7	−3.2	0.02
cg26729380	chr6: 31543655	11.5	7.9	−3.7	*<0.0001	10.6	6.4	−4.2	0.005	11.9	8.4	−3.5	0.001
cg10650821	chr6: 31543686	11.6	10.1	−1.5	0.007	11.4	10.0	−1.4	0.10	11.7	10.2	−1.5	0.03
	chr6: 31544695													65.4	72.4	7.1	0.007	63.2	69.4	6.2	0.36	66.1	73.5	7.4	0.008
	chr6: 31544752													77.2	85.9	8.8	*<0.0001	78.2	86.2	8.0	0.10	76.8	85.9	9.0	*0.0004
	chr6: 31544800													22.7	24.4	1.7	0.01	24.0	26.3	2.3	0.25	22.3	23.8	1.5	0.02
	chr6: 31544822													56.6	62.2	5.6	*0.0005	58.1	62.5	4.4	0.13	56.0	62.1	6.1	0.002
	chr6: 31544848													13.3	13.3	0.0	0.95	14.6	14.0	−0.6	0.51	12.8	13.0	0.2	0.56
cg01360627	chr6: 31544931	70.0	78.6	8.7	*<0.0001	69.8	80.2	10.3	*<0.0001	70.0	78.1	8.0	*<0.0001	25.9	27.3	1.4	0.03	27.4	28.9	1.5	0.26	25.3	26.7	1.4	0.09
cg23384708	chr6: 31544934	64.1	72.2	8.1	*<0.0001	67.4	74.0	6.7	0.004	63.0	71.6	8.6	*<0.0001	74.0	82.5	8.5	*0.0001	77.3	83.9	6.6	0.18	72.8	82.0	9.2	*0.0004
cg20477259	chr6: 31544960	61.6	71.8	10.2	*<0.0001	62.5	73.4	10.9	*<0.0001	61.3	71.3	10.0	*<0.0001	67.9	74.7	6.8	*0.0004	68.9	76.4	7.5	0.09	67.5	74.1	6.6	0.003
	chr6: 31545253													88.1	91.9	3.8	0.003	87.9	92.3	4.4	0.17	88.2	91.8	3.6	0.010
	chr6: 31545258													87.7	91.6	3.8	0.009	88.7	92.2	3.5	0.25	87.4	91.3	3.9	0.02
	chr6: 31545267													82.0	87.8	5.8	*0.0005	84.1	87.8	3.7	0.33	81.3	87.8	6.5	*0.0005
cg15989608	chr6: 31545322	71.3	79.6	8.4	*<0.0001	72.2	80.8	8.7	0.001	70.9	79.1	8.2	*<0.0001	90.4	93.6	3.3	0.01	92.1	91.9	−0.2	0.83	89.8	94.2	4.4	*0.0006
cg26736341	chr6: 31545343	70.0	79.4	9.4	*<0.0001	71.4	80.6	9.3	*0.0008	69.5	79.0	9.4	*<0.0001	78.9	81.0	2.0	0.04	78.0	82.4	4.4	0.28	79.2	80.4	1.3	0.10
	chr6: 31545432													87.0	89.7	2.7	0.17	89.9	91.4	1.5	0.44	85.9	89.1	3.2	0.23
cg04472685	chr6: 31545474	81.4	87.5	6.1	*<0.0001	82.0	87.9	6.0	0.002	81.2	87.4	6.2	*<0.0001	84.0	86.8	2.8	0.008	83.4	87.1	3.6	0.31	84.2	86.7	2.5	0.02
cg19124225	chr6: 31545836	95.6	96.2	0.6	0.15	94.8	96.5	1.7	0.06	95.9	96.1	0.2	0.67
cg02137984	chr6: 31545899	94.7	96.6	1.8	*0.0002	93.7	96.8	3.1	0.006	95.1	96.5	1.4	0.01
cg06825478	chr6: 31546068	90.2	94.3	4.1	*<0.0001	91.0	94.7	3.6	0.01	89.9	94.1	4.2	0.0009	91.8	94.3	2.5	*<0.0001	91.8	94.5	2.6	0.02	91.8	94.2	2.4	*0.0014
	chr6: 31546086													85.1	89.3	4.2	*<0.0001	85.2	89.4	4.3	0.09	85.1	89.3	4.2	*0.0004

diff = post - pre.
underline nominal significance (P < 0.05).
*Significant after correction for multiple testing level (EPIC; P < 0.05/52 = 0.00096, pyrosequencing; P < 0.05/32 = 0.00156).

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Table 3 Changes of DNAm in TNF gene after neurosurgery.

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